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You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-NURR1 (NR4A2)-C-DIM12
C-DIM12

Chemical Structure : C-DIM12

CAS No.: 178946-89-9

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C-DIM12 (C-DIM-12;C-DIM 12)

Catalog No.: PC-45725Not For Human Use, Lab Use Only.

C-DIM12 is a NR4A2 (Nurr1) activator that inhibits NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor CoREST and NCOR2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

C-DIM12 is a NR4A2 (Nurr1) activator that inhibits NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor CoREST and NCOR2.
C-DIM12 decreases NF-κB activation and enchances nuclear translocation of Nurr1 primary microglia.

Physicochemical Properties

M.Wt 356.8475
Formula C23H17ClN2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Indole, 3,3'-[(4-chlorophenyl)methylene]bis-

References

1. De Miranda BR, et al. Mol Pharmacol. 2015 Jun;87(6):1021-34.

2. Hammond SL, et al. Neurosci Lett. 2015 Oct 21;607:83-9.

3. De Miranda BR, et al. J Pharmacol Exp Ther. 2013 Apr;345(1):125-38.

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