| Cat. No. |
Product Name |
Information |
| PC-45725 |
C-DIM12
NURR1 (NR4A2) agonist
|
C-DIM12 is a NR4A2 (Nurr1) activator that inhibits NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor CoREST and NCOR2. |
| PC-21259 |
Nurr1 agonist 5o
NURR1 agonist
|
Nurr1 agonist 5o is a small molecule agonist of the transcription factor Nurr1 with Kd of 0.5 uM and EC50 of 3 uM. |
| PC-21004 |
4A7C-301
Nurr1 agonist
|
4A7C-301 is a potent, selective, brain-penetrant agonist of nuclear receptor Nurr1 with EC50 of 6.53 uM, binds to Nurr1 ligand binding domain (LBD) with IC50 of 50 nM. |
| PC-20774 |
XCT0135908
Nurr1-RXR agonist
|
XCT0135908 (BRF001) is a highly selective activator of Nurr1-RXR heterodimers, stimulates dopamine (DA) neuron survival. |
| PC-20773 |
BRF110
Nurr1-RXRα agonist
|
BRF110 is a potent, selective, brain penetrant and vivo active agonist of Nurr1-RXRα heterodimers with EC50 of 900 nM. |
| PC-20772 |
SA00025
NURR1 agonist
|
SA00025 is a potent, specific and brain penetrant agonist of Nurr1 (NR4A2) with EC50 of 2.5 nM in HEK293 cells transfected with full length human Nurr1. |
| PC-20771 |
Amodiaquine
NURR1 agonist
|
Amodiaquine (Amodiaquin, AQ) is an antimalarial agent and nuclear receptor Nurr1 (NR4A2) agonist, specifically binds to Nurr1-LBD (ligand binding domain) with EC50 of 20 uM. |
| PC-20770 |
Nurr1 inverse agonist 31
Nurr1 modulator
|
Nurr1 inverse agonist 31 is a small molecule inverse agonist of Nurr1 (NR4A2) with IC50 of 2.3 uM, mimicks the effect of Nurr1 silencing on interleukin-6 release from LPS-stimulated human astrocytes. |
| PC-20768 |
Nurr1 agonist 29
NURR1 (NR4A2) agonist
|
Nurr1 agonist 29 is a potent, selective nuclear receptor related 1 (Nurr1, NR4A2) agonist with EC50 of 0.11 uM. |
