Catalog No.: PC-20772Not For Human Use, Lab Use Only.
SA00025 is a potent, specific and brain penetrant agonist of Nurr1 (NR4A2) with EC50 of 2.5 nM in HEK293 cells transfected with full length human Nurr1.
SA00025 is a potent, specific and brain penetrant agonist of Nurr1 (NR4A2) with EC50 of 2.5 nM in HEK293 cells transfected with full length human Nurr1. SA00025 does not activate panel of 40 other nuclear receptors, including RXR. SA00025 (30mg/kg for 7 days, oral gavage) modulated the transcription of dopaminergic target genes in brain of naive rats, induced a transcriptional upregulation of Nurr1, TH and VMAT. SA00025 caused neuroprotection in the 6-OHDA lesion model primed with the TLR3 dsRNA inflammatory stimulant (poly(I:C)). SA00025 displayed anti-inflammatory activity in the 6-OHDA lesion model primed with the TLR3 dsRNA inflammatory stimulant (poly(I:C)).
