Nurr1 inverse agonist 31

Chemical Structure : Nurr1 inverse agonist 31

Catalog No.: PC-20770Not For Human Use, Lab Use Only.

Nurr1 inverse agonist 31 is a small molecule inverse agonist of Nurr1 (NR4A2) with IC50 of 2.3 uM, mimicks the effect of Nurr1 silencing on interleukin-6 release from LPS-stimulated human astrocytes.

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Biological Activity

Nurr1 inverse agonist 31 is a small molecule inverse agonist of Nurr1 (NR4A2) with IC50 of 2.3 uM, mimicks the effect of Nurr1 silencing on interleukin-6 release from LPS-stimulated human astrocytes.

Physicochemical Properties

M.Wt	265.31
Formula	C17H15NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CN(C)C2=C1C=C(C3=CC=CC=C3)C=C2)OC

References

1. Zaienne D, et al. J Med Chem. 2021 Oct 28;64(20):15126-15140.

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