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XCT0135908

Chemical Structure : XCT0135908

CAS No.: 300837-31-4

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XCT0135908 (BRF001, XCT 0135908)

Catalog No.: PC-20774Not For Human Use, Lab Use Only.

XCT0135908 (BRF001) is a highly selective activator of Nurr1-RXR heterodimers, stimulates dopamine (DA) neuron survival.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

XCT0135908 (BRF001) is a highly selective activator of Nurr1-RXR heterodimers, stimulates dopamine (DA) neuron survival.
XCT0135908 (1 uM) is highly selective in activation of heterodimers formed between Gal4-Nurr1 and cotransfected RXR in African green monkey CV-1 cells.|
XCT0135908 is strictly selective for RXR/Nurr1 heterodimers at 1 uM.
The RXR antagonist LG1208 completely abolished activation by XCT0135908.

Physicochemical Properties

M.Wt 345.40
Formula C21H19N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((5-Allyl-6-methyl-2-phenylpyrimidin-4-yl)amino)benzoic acid

References

1. Wallen-Mackenzie A, et al. Genes Dev. 2003 Dec 15;17(24):3036-47.

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