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Chemical Structure : C071-0684
Catalog No.: PC-23289Not For Human Use, Lab Use Only.
C071-0684 is a potent small molecule inhibitor of CHD1L targeting ATP catalytic activity of chromodomain helicase CHD1L (IC50=17.36 uM, KD=0.5 uM), shows IC50 of 13.0 uM against human HCT116 colorectal cancer cells.
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C071-0684 is a potent small molecule inhibitor of CHD1L targeting ATP catalytic activity of chromodomain helicase CHD1L (IC50=17.36 uM, KD=0.5 uM), shows IC50 of 13.0 uM against human HCT116 colorectal cancer cells.
C071-0684 demonstrated more potent inhibition than CHD1Li 6.11 (Cat#PC-72745).
C071-0684 showed a significantly higher capacity for inhibiting cell proliferation in MDA-MB-231 cells, which highly express CHD1L, compared to CHD1L-knockdown MDA-MB-231 cells.
| M.Wt | 614.72 | |
| Formula | C26H29F3N4O4S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang C, et al. Int J Biol Macromol. 2024 Oct 18;281(Pt 4):136678.
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