Chemical Structure : C071-0684
CAS No.:
685836-99-1
C071-0684
Catalog No.: PC-23289Not For Human Use, Lab Use Only.
C071-0684 is a potent small molecule inhibitor of CHD1L targeting ATP catalytic activity of chromodomain helicase CHD1L (IC50=17.36 uM, KD=0.5 uM), shows IC50 of 13.0 uM against human HCT116 colorectal cancer cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
C071-0684 is a potent small molecule inhibitor of CHD1L targeting ATP catalytic activity of chromodomain helicase CHD1L (IC50=17.36 uM, KD=0.5 uM), shows IC50 of 13.0 uM against human HCT116 colorectal cancer cells.
C071-0684 demonstrated more potent inhibition than CHD1Li 6.11 (Cat#PC-72745).
C071-0684 showed a significantly higher capacity for inhibiting cell proliferation in MDA-MB-231 cells, which highly express CHD1L, compared to CHD1L-knockdown MDA-MB-231 cells.
Physicochemical Properties
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M.Wt
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614.72
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Formula
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C26H29F3N4O4S3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-(tert-butyl)-2-(4-((4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl)sulfonyl)butanamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
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References
1. Zhang C, et al. Int J Biol Macromol. 2024 Oct 18;281(Pt 4):136678.
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