C105SR | Cyclophilin inhibitor | Probechem Biochemicals

Chemical Structure : C105SR

C105SR (C 105SR)

Catalog No.: PC-21262Not For Human Use, Lab Use Only.

C105SR is small-molecule cyclophilin inhibitor with IC50 of 5 nM for inhibition of CypD PPIase activity and 9 nM for mitochondrial swelling.

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Biological Activity

C105SR is small-molecule cyclophilin inhibitor with IC50 of 5 nM for inhibition of CypD PPIase activity and 9 nM for mitochondrial swelling.
C105SR inhibits mPTP opening and prevented cell death in a model of hypoxia/reoxygenation.
C105SR protects against hepatic IRI in vivo by reducing hepatocyte necrosis and apoptosis.

Physicochemical Properties

M.Wt	633.61
Formula	C32H33BrN4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((S)-2-((R)-2-(benzo[b]thiophen-7-yl)pyrrolidin-1-yl)-1-(5-bromo-2-methoxyphenyl)-2-oxoethyl)-3-((1,2,3,4-tetrahydroquinolin-6-yl)methyl)urea

References

1. Amel Kheyar, et al. JHEP Rep. 2023 Aug 16;5(11):100876.

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C105SR (C 105SR)

Biological Activity

Physicochemical Properties

References

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