Chemical Structure : C10M
CAS No.:
2824243-53-8
C10M
(CRP inhibitor C10M)
Catalog No.: PC-21057Not For Human Use, Lab Use Only.
C10M is a small molecule inhibitor of C-reactive protein (CRP), inhibits the binding of pCRP to the physiological ligand phosphocholine (PC) with IC50 of 1.5 mM in ELISA assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
C10M is a small molecule inhibitor of C-reactive protein (CRP), inhibits the binding of pCRP to the physiological ligand phosphocholine (PC) with IC50 of 1.5 mM in ELISA assays.
C10M inhibits CRP-induced monocyte adhesion, expression of pro-inflammatory cytokines, and formation of platelet-leukocyte aggregates was evaluated in-vitro.
C10M inhibits pCRP binding to activated platelets and microvesicles and reduces pCRP*/mCRP induced ICAM-1 and VCAM-1 expression on human endothelial cells and activation of leukocytes.
C10M inhibits CRP-induced aggravation of renal ischemia/reperfusion injury, inhibits pCRP*/mCRP-induced aggravation of allograft rejection in a hindlimb transplantation model.
Physicochemical Properties
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M.Wt
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251.31
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Formula
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C11H26NO3P
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3-(dibutylamino)propyl)phosphonic acid
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