Catalog No.: PC-21057Not For Human Use, Lab Use Only.
C10M is a small molecule inhibitor of C-reactive protein (CRP), inhibits the binding of pCRP to the physiological ligand phosphocholine (PC) with IC50 of 1.5 mM in ELISA assays.
C10M is a small molecule inhibitor of C-reactive protein (CRP), inhibits the binding of pCRP to the physiological ligand phosphocholine (PC) with IC50 of 1.5 mM in ELISA assays.
C10M inhibits CRP-induced monocyte adhesion, expression of pro-inflammatory cytokines, and formation of platelet-leukocyte aggregates was evaluated in-vitro.
C10M inhibits pCRP binding to activated platelets and microvesicles and reduces pCRP*/mCRP induced ICAM-1 and VCAM-1 expression on human endothelial cells and activation of leukocytes.
C10M inhibits CRP-induced aggravation of renal ischemia/reperfusion injury, inhibits pCRP*/mCRP-induced aggravation of allograft rejection in a hindlimb transplantation model.
Physicochemical Properties
M.Wt
251.31
Formula
C11H26NO3P
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(3-(dibutylamino)propyl)phosphonic acid
References
1. Ylenia Pastorello, et al. Int J Mol Sci. 2024 Mar 7;25(6):3097.
