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Chemical Structure : C1632
CAS No.: 108825-65-6
Catalog No.: PC-70001Not For Human Use, Lab Use Only.
C1632 (Lin28-IN-1632) is a small molecule inhibitor of RNA binding protein Lin28 that blocks the Lin28/let-7 interaction, rescues let-7 processing and function in Lin28-expressing cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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C1632 (Lin28-IN-1632) is a small molecule inhibitor of RNA binding protein Lin28 that blocks the Lin28/let-7 interaction, rescues let-7 processing and function in Lin28-expressing cancer cells.
C1632 inhibits Lin28A from pre-let-7a-2 binding at IC50 of 8 uM; induces differentiation of mouse embryonic stem cells, and reduces tumor-sphere formation by 22Rv1 and Huh7 cells.
C1632 inhibits proliferation and stem-like properties in human cancer cells (22Rv1, PC3, DU145, and Huh7) with GI50 of 20-80 uM.
| M.Wt | 281.3 | |
| Formula | C15H15N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide |
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1. Roos M, et al. ACS Chem Biol. 2016 Oct 21;11(10):2773-2781.
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