C191-0266

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Chemical Structure : C191-0266

Catalog No.: PC-26496Not For Human Use, Lab Use Only.

C191-0266 is a small molecule inhibitor of METTL3 with KD of 7.28 uM and enzymatic IC50 of 7.84 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

C191-0266 is a small molecule inhibitor of METTL3 with KD of 7.28 uM and enzymatic IC50 of 7.84 uM.
C191-0266 inhibits the proliferation of OCI-AML3, MOLM-13, and THP-1 cell lines with IC50 values of 16.91 uM, 19.01 uM, and 24.99 uM, respectively..
C191-0266 enhances Ara-C's cytotoxicity by suppressing Ara-C-induced protective autophagy.
C191-0266 regulates the NF-κB pathway to inhibit TNF-α overexpression in Ara-C-resistant cell lines.

Physicochemical Properties

M.Wt	494.59
Formula	C27H34N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((6,7-dimethoxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methyl)-N-(3-(4-methylpiperidin-1-yl)propyl)benzamide

References

1. Hu X, et al. Leuk Res. 2026 Jan 20;165:108167.

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C191-0266

Biological Activity

Physicochemical Properties

References

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