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C2-8

Chemical Structure : C2-8

CAS No.: 300670-16-0

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C2-8 (polyQ aggregation inhibitor C2-8)

Catalog No.: PC-70247Not For Human Use, Lab Use Only.

C2-8 is a small molecule inhibitor of polyglutamine (polyQ) aggregation in Huntington's disease neurons.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    C2-8 is a small molecule inhibitor of polyglutamine (polyQ) aggregation in Huntington's disease neurons.
    C2-8 efficiently inhibits aggregation in PC12 cells with IC50 of 50 nM; suppresses neurodegeneration in a Drosophila model of HD.
    C2-8 penetrates the blood-brain barrier, shows improved motor performance and reduces neuronal atrophy and has smaller huntingtin aggregates in mice.

    Physicochemical Properties

    M.Wt 510.2
    Formula C19H14Br2N2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-bromophenyl)-3-{[(4-bromophenyl)amino]sulfonyl}benzamide

    References

    1. Zhang X, et al. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):892-7.

    2. Wang N, et al. J Huntingtons Dis. 2013;2(4):443-51.

    3. Chopra V, et al. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16685-9.

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