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Chemical Structure : C2-8
Catalog No.: PC-70247Not For Human Use, Lab Use Only.
C2-8 is a small molecule inhibitor of polyglutamine (polyQ) aggregation in Huntington's disease neurons.
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C2-8 is a small molecule inhibitor of polyglutamine (polyQ) aggregation in Huntington's disease neurons.
C2-8 efficiently inhibits aggregation in PC12 cells with IC50 of 50 nM; suppresses neurodegeneration in a Drosophila model of HD.
C2-8 penetrates the blood-brain barrier, shows improved motor performance and reduces neuronal atrophy and has smaller huntingtin aggregates in mice.
| M.Wt | 510.2 | |
| Formula | C19H14Br2N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang X, et al. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):892-7.
2. Wang N, et al. J Huntingtons Dis. 2013;2(4):443-51.
3. Chopra V, et al. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16685-9.
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