Chemical Structure : C220
CAS No.:
1989620-03-2
C220
(PRMT5 inhibitor C220)
Catalog No.: PC-21273Not For Human Use, Lab Use Only.
C220 (PRMT5 inhibitor C220) is a highly potent, selective and SAM cpmpetitive inhibitor of protein arginine methyltransferase 5 (PRMT5) with IC50 of 2.4 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
C220 (PRMT5 inhibitor C220) is a highly potent, selective and SAM cpmpetitive inhibitor of protein arginine methyltransferase 5 (PRMT5) with IC50 of 2.4 nM.
C220 reduces mouse and human allogeneic T cell proliferation and inflammatory IFN-γ and IL-17 cytokine production.
C220 improves survival, reducing disease incidence and clinical severity in mouse models of aGVHD without adversely affecting engraftment in vivo.
C220 deregulates the cell cycle in activated T cells and disrupts signaling by affecting ERK1/2 phosphorylation.
C220 broadly suppresses DDR Gene expression in ovarian and breast cancer cells, C220 dysregulates chromatin- and splicing-mediated regulation of DDR pathways.
C220 induces DNA repair deficiency, and synergizes with PARP inhibition and chemotherapy in vitro and in vivo.
Physicochemical Properties
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M.Wt
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376.80
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Formula
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C17H17ClN4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-chlorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol
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References
1. Katiri J Snyder, et al. JCI Insight. 2020 Apr 23;5(8):e131099.
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