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Chemical Structure : C220
Catalog No.: PC-21273Not For Human Use, Lab Use Only.
C220 (PRMT5 inhibitor C220) is a highly potent, selective and SAM cpmpetitive inhibitor of protein arginine methyltransferase 5 (PRMT5) with IC50 of 2.4 nM.
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C220 (PRMT5 inhibitor C220) is a highly potent, selective and SAM cpmpetitive inhibitor of protein arginine methyltransferase 5 (PRMT5) with IC50 of 2.4 nM.
C220 reduces mouse and human allogeneic T cell proliferation and inflammatory IFN-γ and IL-17 cytokine production.
C220 improves survival, reducing disease incidence and clinical severity in mouse models of aGVHD without adversely affecting engraftment in vivo.
C220 deregulates the cell cycle in activated T cells and disrupts signaling by affecting ERK1/2 phosphorylation.
C220 broadly suppresses DDR Gene expression in ovarian and breast cancer cells, C220 dysregulates chromatin- and splicing-mediated regulation of DDR pathways.
C220 induces DNA repair deficiency, and synergizes with PARP inhibition and chemotherapy in vitro and in vivo.
| M.Wt | 376.80 | |
| Formula | C17H17ClN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Katiri J Snyder, et al. JCI Insight. 2020 Apr 23;5(8):e131099.
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