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Chemical Structure : C3aR antagonist JR14a
CAS No.: 2411440-41-8
Catalog No.: PC-72006Not For Human Use, Lab Use Only.
C3aR antagonist JR14a is a potent and selective antagonist of human Complement C3a receptor (hC3aR) with IC50 of 10 nM (Inhibition of intracellular Ca2+ release induced by 100 nM C3a).
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| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
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C3aR antagonist JR14a is a potent and selective antagonist of human Complement C3a receptor (hC3aR) with IC50 of 10 nM (Inhibition of intracellular Ca2+ release induced by 100 nM C3a).
JR14a shows no agonist activity against hC3aR and 100-fold more potent than SB290157 (Cat. PC-60789).
JR14a inhibited β-hexosaminidase secretion (IC50=8 nM) from human LAD2 mast cells degranulated by 100 nM C3a.
JR14a demonstarted anti-inflammatory activity against agonist-induced paw edema in male Wistar rats.
| M.Wt | 533.468 | |
| Formula | C25H26Cl2N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5-(bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-L-arginine |
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1. Jessica A Rowley, et al. J Med Chem. 2020 Jan 23;63(2):529-541.
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