Catalog No.: PC-72006Not For Human Use, Lab Use Only.
C3aR antagonist JR14a is a potent and selective antagonist of human Complement C3a receptor (hC3aR) with IC50 of 10 nM (Inhibition of intracellular Ca2+ release induced by 100 nM C3a).
C3aR antagonist JR14a is a potent and selective antagonist of human Complement C3a receptor (hC3aR) with IC50 of 10 nM (Inhibition of intracellular Ca2+ release induced by 100 nM C3a).
JR14a shows no agonist activity against hC3aR and 100-fold more potent than SB290157 (Cat. PC-60789).
JR14a inhibited β-hexosaminidase secretion (IC50=8 nM) from human LAD2 mast cells degranulated by 100 nM C3a.
JR14a demonstarted anti-inflammatory activity against agonist-induced paw edema in male Wistar rats.
