Chemical Structure : CAB-01-019
CAS No.:
2826198-44-9
CAB-01-019
(D4R antagonist 16f)
Catalog No.: PC-21105Not For Human Use, Lab Use Only.
CAB-01-019 is potent, selective dopamine D4 receptor (D4R) full antagonist with binding Ki of 2.2 nM, >500-fold selectivity over D2R and D3R.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CAB-01-019 is potent, selective dopamine D4 receptor (D4R) full antagonist with binding Ki of 2.2 nM, >500-fold selectivity over D2R and D3R.
CAB-01-019 demonstrates excellent D4R selectivity in functional assays and is a competitive antagonist at D4R.
CAB-01-019 is a potent full D4R antagonist for β-arrestin recruitment with no D4R agonist activity.
CAB-01-019 is a potent low-efficacy D4R partial agonist, metabolically stable in rat and human liver microsomes, and has excellent brain penetration in rats.
CAB-01-019 (5, 15, and 30 mg/kg, i.p.) dose-dependently decreased food-maintained responding in male Fisher F344 rats, decreases iv cocaine self-administration in rats.
Physicochemical Properties
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M.Wt
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338.47
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Formula
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C19H22N4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(3-(4-(Pyridin-2-yl)piperazin-1-yl)propyl)benzo[d]thiazole
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References
1. Comfort A. Boateng, et al. Journal of Medicinal Chemistry 2023.
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