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Chemical Structure : CAB-01-019
Catalog No.: PC-21105Not For Human Use, Lab Use Only.
CAB-01-019 is potent, selective dopamine D4 receptor (D4R) full antagonist with binding Ki of 2.2 nM, >500-fold selectivity over D2R and D3R.
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CAB-01-019 is potent, selective dopamine D4 receptor (D4R) full antagonist with binding Ki of 2.2 nM, >500-fold selectivity over D2R and D3R.
CAB-01-019 demonstrates excellent D4R selectivity in functional assays and is a competitive antagonist at D4R.
CAB-01-019 is a potent full D4R antagonist for β-arrestin recruitment with no D4R agonist activity.
CAB-01-019 is a potent low-efficacy D4R partial agonist, metabolically stable in rat and human liver microsomes, and has excellent brain penetration in rats.
CAB-01-019 (5, 15, and 30 mg/kg, i.p.) dose-dependently decreased food-maintained responding in male Fisher F344 rats, decreases iv cocaine self-administration in rats.
| M.Wt | 338.47 | |
| Formula | C19H22N4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Comfort A. Boateng, et al. Journal of Medicinal Chemistry 2023.
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