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CAB2-015

Chemical Structure : CAB2-015

CAS No.: 1801985-53-4

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CAB2-015 (CAB 2-015)

Catalog No.: PC-47103Not For Human Use, Lab Use Only.

CAB2-015 is a high affinity dopamine D3 receptor (D3R) antagonist/partial agonist withIC50 of 7.4 nM, Ki of 0.351 nM, 45-fold selectivity over D2R.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CAB2-015 is a high affinity dopamine D3 receptor (D3R) antagonist/partial agonist withIC50 of 7.4 nM, Ki of 0.351 nM, 45-fold selectivity over D2R.
    CAB2-015 (0.4-10 mg/kg, i.p.) dose-dependently decreased oxycodone self-administration, and shifted the oxycodone dose-response curve downward in rats.
    CAB2-015 facilitated extinction and inhibited oxycodone-induced reinstatement of drug-seeking behavior.
    CAB2-015 also dose-dependently decreased oxycodone-enhanced locomotor activity.

    Physicochemical Properties

    M.Wt 438.575
    Formula C28H30N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(4-(naphthalen-1-yl)piperazin-1-yl)butyl)quinoline-3-carboxamide

    References

    1. Zhi-Bing You, et al. Neuropharmacology. 2017 Nov;126:190-199.

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