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Chemical Structure : CAB2-015
Catalog No.: PC-47103Not For Human Use, Lab Use Only.
CAB2-015 is a high affinity dopamine D3 receptor (D3R) antagonist/partial agonist withIC50 of 7.4 nM, Ki of 0.351 nM, 45-fold selectivity over D2R.
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CAB2-015 is a high affinity dopamine D3 receptor (D3R) antagonist/partial agonist withIC50 of 7.4 nM, Ki of 0.351 nM, 45-fold selectivity over D2R.
CAB2-015 (0.4-10 mg/kg, i.p.) dose-dependently decreased oxycodone self-administration, and shifted the oxycodone dose-response curve downward in rats.
CAB2-015 facilitated extinction and inhibited oxycodone-induced reinstatement of drug-seeking behavior.
CAB2-015 also dose-dependently decreased oxycodone-enhanced locomotor activity.
| M.Wt | 438.575 | |
| Formula | C28H30N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhi-Bing You, et al. Neuropharmacology. 2017 Nov;126:190-199.
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