4Q3C is a selective CB2 receptor agonist, has selectivity index 10,000 more over CB1. 4Q3C significantly inhibits the mechanosensitivity of mucosal bladder afferents to stroking. 4Q3C significantly reduces the severity of arthritis, decreased histopathological findings, and markedly reduced bone erosion in collagen-induced arthritis (CIA) mice. 4Q3C prevents an increase in the nuclear factor-κB ligand (RANKL)/osteoprotegerin (OPG) ratio and inhibits the formation of osteoclasts in CIA mice.
Physicochemical Properties
M.Wt
188.19
Formula
C10H8N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-quinolone-3-carboxyamide
References
1. Bai J, et al. Biomed Pharmacother. 2019 Aug;116:109025.
2. Christie S, et al. Am J Physiol Renal Physiol. 2021 May 1;320(5):F859-F865.
3. Pasquini S, et al. J Med Chem 54: 5444-5453, 2011.
