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CBB3001

Chemical Structure : CBB3001

CAS No.: 1639358-50-1

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CBB3001 (CBB-3001, CBB 3001)

Catalog No.: PC-35295Not For Human Use, Lab Use Only.

CBB3001 (CBB-3001) is a novel potent, selective histone demethylase LSD1 inhibitor with IC50 of 21.25 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CBB3001 (CBB-3001) is a potent, selective histone demethylase LSD1 inhibitor with IC50 of 21.25 uM.
    CBB3001 potently inhibits LSD1 activity both in vitro and in vivo.
    CBB3001 also selectively inhibits the growth of human ovarian teratocarcinoma PA-1 and mouse embryonic carcinoma F9 cells.
    CBB3001 caused the downregulation of pluripotent stem cell proteins SOX2 and OCT4, does not have significant inhibition on the growth of human colorectal carcinoma HCT116 cells or mouse fibroblast NIH3T3 cells that do not express these stem cell proteins.

    Physicochemical Properties

    M.Wt 349.427
    Formula C19H27NO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    tert-butyl 2-(4-(tert-butoxycarbonyloxy)phenyl)cyclopropylcarbamate

    References

    1. Hoang N, et al. Bioorg Med Chem. 2018 May 1;26(8):1523-1537.

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