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CBLC000

Chemical Structure : CBLC000

CAS No.: 1197996-83-0

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CBLC000 (CBL0100)

Catalog No.: PC-72241Not For Human Use, Lab Use Only.

CBLC000 (CBL0100) is a small molecule histone chaperone FACT inhibitor, activates p53 and inhibits NF-κB with EC50 of 0.06 and 0.03 uM in cell-based p53 and NF-κB reporter assays, respecitvely.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CBLC000 (CBL0100) is a small molecule histone chaperone FACT inhibitor, activates p53 and inhibits NF-κB with EC50 of 0.06 and 0.03 uM in cell-based p53 and NF-κB reporter assays, respecitvely.
    CBLC000 blocks emergence of iPSC colonies from primary MEFs, does not affect either the growth or undifferentiated state of established pluripotent cells.

    Physicochemical Properties

    M.Wt 374.484
    Formula C24H26N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(2-(diethylamino)ethyl)-1,6,10,11-tetrahydro-3H-dicyclopenta[c,g]carbazole-3,9(2H)-dione

    References

    1. Alexander V Gasparian, et al. Sci Transl Med. 2011 Aug 10;3(95):95ra74.

    2. Zuolian Shen, et al. Stem Cells Dev. 2018 Dec 15;27(24):1693-1701.

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