CBP bromodomain inhibitor 27 | CBP bromodomain inhibitor

Chemical Structure : CBP bromodomain inhibitor 27

CBP bromodomain inhibitor 27 (CBP-IN-27)

Catalog No.: PC-21984Not For Human Use, Lab Use Only.

CBP-IN-27 is a potent, selective CBP bromodomain inhibitor with IC50 of 3.6 nM, displays exquisite selectivity over BRD4(1) (IC50=11 uM) and the broader bromodomain family.

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Biological Activity

CBP-IN-27 is a potent, selective CBP bromodomain inhibitor with IC50 of 3.6 nM, displays exquisite selectivity over BRD4(1) (IC50=11 uM) and the broader bromodomain family.

Physicochemical Properties

M.Wt	508.57
Formula	C27H30F2N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1,3-dimethyl-4-morpholino-1,3-dihydro-2H-benzo[d]imidazol-2-one

References

1. Bronner SM, et al. J Med Chem. 2017 Dec 28;60(24):10151-10171.

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CBP bromodomain inhibitor 27 (CBP-IN-27)

Biological Activity

Physicochemical Properties

References

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