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CBP bromodomain inhibitor 29

Chemical Structure : CBP bromodomain inhibitor 29

CAS No.: 2161357-02-2

CBP bromodomain inhibitor 29 (CBP-IN-29)

Catalog No.: PC-21985Not For Human Use, Lab Use Only.

CBP-IN-29 is a potent, selective CBP bromodomain inhibitor with IC50 of 2.2 nM, displays exquisite selectivity over BRD4(1) (IC50=23 uM) and the broader bromodomain family.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CBP-IN-29 is a potent, selective CBP bromodomain inhibitor with IC50 of 2.2 nM, displays exquisite selectivity over BRD4(1) (IC50=23 uM) and the broader bromodomain family.

Physicochemical Properties

M.Wt 478.55
Formula C26H28F2N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(7-(Difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-7-isopropyl-N-methyl-1H-pyrrolo[2,3-c]pyridine-3-carboxamide

References

1. Bronner SM, et al. J Med Chem. 2017 Dec 28;60(24):10151-10171.

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