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CBR-096-4

Chemical Structure : CBR-096-4

CAS No.: 1776931-05-5

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CBR-096-4 (CBR 096 4)

Catalog No.: PC-70281Not For Human Use, Lab Use Only.

CBR-096-4 is a derivative of the antifungal drug itraconazole (ITA) as an inhibitor of MFB cell fate in resident fibroblasts derived from multiple murine and human tissues.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CBR-096-4 is a derivative of the antifungal drug itraconazole (ITA) as an inhibitor of MFB cell fate in resident fibroblasts derived from multiple murine and human tissues.
    CBR-096-4 is devoid of antifungal and human cytochrome P450 inhibitory activity with excellent pharmacokinetics, safety, and efficacy in rodent models of lung, liver, and skin fibrosis.

    Physicochemical Properties

    M.Wt 636.757
    Formula C35H40N8O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-(4-(4-(((2R,4S)-2-((2H-1,2,3-triazol-2-yl)methyl)-2-phenyl-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

    References

    1. Bollong MJ, et al. Proc Natl Acad Sci U S A. 2017 May 2;114(18):4679-4684.

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