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Chemical Structure : CC-115
CAS No.: 1228013-15-7
Catalog No.: PC-21706Not For Human Use, Lab Use Only.
CC-115 is a potent, selective, dual DNA-PK and mTOR kinase inhibitor with IC50 of 13 nM and 21 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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CC-115 is a potent, selective, dual DNA-PK and mTOR kinase inhibitor with IC50 of 13 nM and 21 nM, respectively.
CC-115 inhibits PC-3 cells proliferation with with IC50 of 138 nM.
CC-115 blocks both mTORC1(pS6) and mTORC2(pAktS473) signaling in PC-3 cancer cells, in vitro and in vivo.
CC-115 blocks proliferation induced by CD40(+) interleukin-21 stimulation in primary CLL cells.
| M.Wt | 336.36 | |
| Formula | C16H16N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one |
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1. Mortensen DS, et al. J Med Chem. 2015 Jul 23;58(14):5599-608.
2. Thijssen R, et al. Blood. 2016 Jul 28;128(4):574-83.
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