| Cat. No. |
Product Name |
Information |
| PC-73106 |
AZD7648
DNA-PK inhibitor
|
AZD7648 (AZD-7648) is a potent, selective inhibitor of DNA-PK catalytic subunit (DNA-PKcs) with IC50 of 0.6 nM. |
| PC-63031 |
KU-0060648
|
KU-006064 is a potent, dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3K (IC50=4/0.5/0.1 nM for PI3Kα/β/δ). |
| PC-61971 |
VX-984
DNA-PK inhibitor
|
VX-984 (M9831) is a potent, selective inhibitor of DNA-PK with IC50 of 88 nM for inhibition of DNA-PKcs autophosphorylation (Ser2056) in A549 lung cancer cells, with good selectivity versus other PI3K family members. |
| PC-61389 |
M3814
DNA-PK inhibitor
|
M3814 (Nedisertib, Peposertib, MSC2490484A) is a highly potent, selective, ATP-competitive and orally bioavailable inhibitor of DNA-PK with IC50 of 0.6 nM (10 uM ATP). |
| PC-42782 |
NU-7441
DNA-PK inhibitor
|
NU-7441 (KU 57788) is a highly potent and selective DNA-PK inhibitor (IC50=14 nM). |
| PC-21706 |
CC‐115
DNA-PK/mTOR inhibitor
|
CC-115 is a potent, selective, dual DNA-PK and mTOR kinase inhibitor with IC50 of 13 nM and 21 nM, respectively. |
| PC-21129 |
ZL-2201 mesylate
DNA-PK inhibitor
|
ZL-2201 mesylate (ZL2201) is a highly potent, selective and orally bioavailable inhibitor of DNA-dependent protein kinase (DNA-PK) with IC50 of 1.1 nM. |
| PC-21128 |
ZL-2201
DNA-PK inhibitor
|
ZL-2201 (ZL2201) is a highly potent, selective and orally bioavailable inhibitor of DNA-dependent protein kinase (DNA-PK) with IC50 of 1.1 nM. |
| PC-20221 |
SN38023
DNA-PK inhibitor
|
SN38023 is a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361 (Cat# PC-62995), SN38023 is metabolised to a potent DNA-PKi (IC87361) selectively in radioresistant hypoxic cells. |
| PC-20171 |
Ku-DBi 245
DNA-PK inhibitor
|
Ku-DBi 245 is a novel DNA-PK inhibitor with a unique mechanism of action, blocking the Ku 70/80 heterodimer interaction with DNA. |
| PC-72056 |
BAY-8400
DNA-PK inhibitor
|
BAY-8400 (BAY8400) is a highly potent, selective inhibitor of DNA-PK with biochemical IC50 of 81 nM, cellular IC50 of 69 nM (γH2AX in HT-144). |
| PC-72041 |
NU5455
DNA-PK inhibitor
|
NU5455 (NU-5455) is a potent, highly selective, oral inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity with IC50 of 8.2 nM. |
