| Cat. No. |
Product Name |
Information |
| PC-73106 |
AZD7648
DNA-PK inhibitor
|
AZD7648 (AZD-7648) is a potent, selective inhibitor of DNA-PK catalytic subunit (DNA-PKcs) with IC50 of 0.6 nM. |
| PC-43460 |
PIK-75
p110α inhibitor
|
PIK-75 is a potent, isoform-selective p110α inhibitor with IC50 of 0.3 nM, displays >100-fold selectivity over p110β, p110δ and PI3K C2b. |
| PC-63031 |
KU-0060648
DNA-PK/PI3K inhibitor
|
KU-0060648 (KU 60648) is a potent, dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3K (IC50=4/0.5/0.1 nM for PI3Kα/β/δ). |
| PC-62996 |
IC 86621
DNA-PK inhibitor
|
IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM). |
| PC-62995 |
IC 87361
DNA-PK inhibitor
|
IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β. |
| PC-61971 |
VX-984
DNA-PK inhibitor
|
VX-984 (M9831) is a potent, selective inhibitor of DNA-PK with IC50 of 88 nM for inhibition of DNA-PKcs autophosphorylation (Ser2056) in A549 lung cancer cells, with good selectivity versus other PI3K family members. |
| PC-61970 |
SU-11752
DNA-PK inhibitor
|
SU-11752 is a potent, selective inhibitor of DNA-PK, >500-fold selectivity over PI3Kγ, inhibits DNA double-strand break repair in cells and sensitizs ionizing radiation in cancer cells. |
| PC-61389 |
M3814
DNA-PK inhibitor
|
M3814 (Nedisertib, Peposertib, MSC2490484A) is a highly potent, selective, ATP-competitive and orally bioavailable inhibitor of DNA-PK with IC50 of 0.6 nM (10 uM ATP). |
| PC-70103 |
NU-7163
DNA-PK inhibitor
|
NU-7163 is a poten and selective, ATP-competitive DNA-PK inhibitor with IC50 of 0.19 uM, Ki of 24 nM. |
| PC-45615 |
Compound 401
DNA-PK inhibitor
|
A synthetic inhibitor of DNA-PK also inhibits mTOR (IC50=5.3 uM). |
| PC-42782 |
NU-7441
DNA-PK inhibitor
|
NU-7441 (KU 57788) is a highly potent and selective DNA-PK inhibitor (IC50=14 nM). |
| PC-21706 |
CC‐115
DNA-PK/mTOR inhibitor
|
CC-115 is a potent, selective, dual DNA-PK and mTOR kinase inhibitor with IC50 of 13 nM and 21 nM, respectively. |
