Ku-DBi 245 is a novel DNA-PK inhibitor with a unique mechanism of action, blocking the Ku 70/80 heterodimer interaction with DNA.
Ku-DBi 245 does not affect the cellular viability, but potentiates the cellular effects of bleomycin through inhibition of DNA-PKcs autophosphorylation events at S2056.
Ku-DBi 245 modulates the DNA damage response in response to DNA double-strand breaks.
Ku-DBi 245 impacts the ATM DDR signaling pathway in NSCLC cells, the phosphorylation of p53 is increased by bleomycin treatment and further increased by 245 combination treatment.
