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Ku-DBi 245

Chemical Structure : Ku-DBi 245

CAS No.: 2161403-77-4

Ku-DBi 245 (Ku-DBi245)

Catalog No.: PC-20171Not For Human Use, Lab Use Only.

Ku-DBi 245 is a novel DNA-PK inhibitor with a unique mechanism of action, blocking the Ku 70/80 heterodimer interaction with DNA.

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    Biological Activity

    Ku-DBi 245 is a novel DNA-PK inhibitor with a unique mechanism of action, blocking the Ku 70/80 heterodimer interaction with DNA.
    Ku-DBi 245 does not affect the cellular viability, but potentiates the cellular effects of bleomycin through inhibition of DNA-PKcs autophosphorylation events at S2056.
    Ku-DBi 245 modulates the DNA damage response in response to DNA double-strand breaks.
    Ku-DBi 245 impacts the ATM DDR signaling pathway in NSCLC cells, the phosphorylation of p53 is increased by bleomycin treatment and further increased by 245 combination treatment.

    Physicochemical Properties

    M.Wt 582.02
    Formula C30H24ClN7O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-(5-((1-(3-(1H-tetrazol-5-yl)phenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)methyl)furan-2-yl)-2-chloro-N-(3-methoxyphenyl)benzamide

    References

    1. Mendoza-Munoz PL, et al. NAR Cancer. 2023 Feb 6;5(1):zcad003.

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