Ku-DBi 3392 | Ku-DNA inhibitor | Probechem Biochemicals

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Chemical Structure : Ku-DBi 3392

Ku-DBi 3392 (GL-3392)

Catalog No.: PC-23583Not For Human Use, Lab Use Only.

Ku-DBi 3392 (GL-3392) is a small molecule Ku-DNA binding inhibitor with IC50 of 2.4 uM, shows direct interaction with Ku70-Ku80 with MST Kd of 2.1 uM, exhibits IC50 of 0.77 uM for DNA-PK.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Ku-DBi 3392 (GL-3392) is a small molecule Ku-DNA binding inhibitor with IC50 of 2.4 uM, shows direct interaction with Ku70-Ku80 with MST Kd of 2.1 uM, exhibits IC50 of 0.77 uM for DNA-PK.
Ku-DBi 3392 (GL-3392) effectively reversed the IR-induced DNA-PKcs autophosphorylation in A549 NSCLC adenocarcinoma xenograft model.
Ku-DBi 3392 (GL-3392) inhibited DNA-PK and enhanced a radiation-dependent decrease in tumor cell proliferation.

Physicochemical Properties

M.Wt	640.57
Formula	C35H23F3N2O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-(3-((5-(4-methoxy-3-((3-(trifluoromethoxy)phenyl)carbamoyl)phenyl)furan-2-yl)methylene)-2-oxoindolin-1-yl)benzoic acid

References

1. Mendoza-Munoz PL, ET AL. Cancers (Basel). 2024 Sep 26;16(19):3286.

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Ku-DBi 3392 (GL-3392)

Biological Activity

Physicochemical Properties

References

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