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IC 86621

Chemical Structure : IC 86621

CAS No.: 404009-40-1

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IC 86621 (IC86621, IC-86621)

Catalog No.: PC-62996Not For Human Use, Lab Use Only.

IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM).
IC 86621 directly inhibits the repair of DNA DSBs and consequently enhances the cytotoxicity of physical and chemical agents that induce DSBs but not other DNA lesions.

Physicochemical Properties

M.Wt 221.256
Formula C12H15NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-hydroxy-4-morpholinophenyl)ethanone

References

1. Kashishian A, et al. Mol Cancer Ther. 2003 Dec;2(12):1257-64.

2. Allen C, et al. Mol Cancer Res. 2003 Oct;1(12):913-20.

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