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Chemical Structure : KU-0060648
CAS No.: 881375-00-4
Catalog No.: PC-63031Not For Human Use, Lab Use Only.
KU-0060648 (KU 60648) is a potent, dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3K (IC50=4/0.5/0.1 nM for PI3Kα/β/δ).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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KU-0060648 (KU 60648) is a potent, dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3K (IC50=4/0.5/0.1 nM for PI3Kα/β/δ).
KU-0060648 shows selectively over other PI-3K-like kinases, such as ATM, ATR and mTOR.
KU-0060648 inhibits cellular DNA-PK autophosphorylation with IC50 of 19 nM (MCF7 cells) and 170 nM (SW620 cells).
KU-0060648 reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
| M.Wt | 582.719 | |
| Formula | C33H34N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide |
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1. Munck JM, et al. Mol Cancer Ther. 2012 Aug;11(8):1789-98.
2. Robert F, et al. Genome Med. 2015 Aug 27;7:93.
3. Chen MB, et al. Oncotarget. 2016 Mar 29;7(13):17047-59.
4. Mao M, et al. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1244-1249.
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