KU-0060648 (KU 60648) is a potent, dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3K (IC50=4/0.5/0.1 nM for PI3Kα/β/δ).
KU-0060648 shows selectively over other PI-3K-like kinases, such as ATM, ATR and mTOR.
KU-0060648 inhibits cellular DNA-PK autophosphorylation with IC50 of 19 nM (MCF7 cells) and 170 nM (SW620 cells).
KU-0060648 reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.
