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Chemical Structure : DA-143
Catalog No.: PC-23022Not For Human Use, Lab Use Only.
DA-143 is a potent, selective inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) with IC50 of 2.5 nM.
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DA-143 is a potent, selective inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) with IC50 of 2.5 nM.
DA-143 displayed an IC50 for mTOR, PI3KΔ, and ATM at 280 nM, 106 nM and 6,594 nM respectively.
DA-143 sensitizes cancer cells to doxorubicin, blocks phosphorylation of DNA-PKcs substrates.
DA-143 prevents proper T cell activation, reduces T cell proliferation and IL2 cytokine production.
| M.Wt | 576.72 | |
| Formula | C34H32N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Waldrip ZJ, et al. Sci Rep. 2024 Aug 28;14(1):19999.
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