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DA-143

Chemical Structure : DA-143

CAS No.:

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DA-143 (DA143)

Catalog No.: PC-23022Not For Human Use, Lab Use Only.

DA-143 is a potent, selective inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) with IC50 of 2.5 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DA-143 is a potent, selective inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) with IC50 of 2.5 nM.
DA-143 displayed an IC50 for mTOR, PI3KΔ, and ATM at 280 nM, 106 nM and 6,594 nM respectively.
DA-143 sensitizes cancer cells to doxorubicin, blocks phosphorylation of DNA-PKcs substrates.
DA-143 prevents proper T cell activation, reduces T cell proliferation and IL2 cytokine production.

Physicochemical Properties

M.Wt 576.72
Formula C34H32N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-morpholino-8-(8-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrazol-4-yl)dibenzo[b,d]thiophen-4-yl)-4H-chromen-4-one

References

1. Waldrip ZJ, et al. Sci Rep. 2024 Aug 28;14(1):19999.

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