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Chemical Structure : CC-90005
Catalog No.: PC-72784Not For Human Use, Lab Use Only.
CC-90005 (CC90005) is a potent, selective PKC-θ inhibitor with IC50 of 8 nM, >500-fold selectivity over PKC-γ.
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CC-90005 (CC90005) is a potent, selective PKC-θ inhibitor with IC50 of 8 nM, >500-fold selectivity over PKC-γ.
CC-90005 demonstrated exquisite general kinase selectivity, cellular inhibition of T cell activation as assessed by IL-2 expression.
CC-90005 exhibited in vivo efficacy in models of acute and chronic T cell activation with oral dosing.
| M.Wt | 447.491 | |
| Formula | C21H27F2N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patrick Papa, et al. J Med Chem. 2021 Aug 26;64(16):11886-11903.
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