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CC-90005

Chemical Structure : CC-90005

CAS No.: 1799574-70-1

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CC-90005 (CC90005)

Catalog No.: PC-72784Not For Human Use, Lab Use Only.

CC-90005 (CC90005) is a potent, selective PKC-θ inhibitor with IC50 of 8 nM, >500-fold selectivity over PKC-γ.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CC-90005 (CC90005) is a potent, selective PKC-θ inhibitor with IC50 of 8 nM, >500-fold selectivity over PKC-γ.
    CC-90005 demonstrated exquisite general kinase selectivity, cellular inhibition of T cell activation as assessed by IL-2 expression.
    CC-90005 exhibited in vivo efficacy in models of acute and chronic T cell activation with oral dosing.

    Physicochemical Properties

    M.Wt 447.491
    Formula C21H27F2N7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(((4-(2,2-difluoropropoxy)pyrimidin-5-yl)methyl)amino)-4-(((1R,4S)-4-hydroxy-3,3-dimethylcyclohexyl)amino)pyrimidine-5-carbonitrile

    References

    1. Patrick Papa, et al. J Med Chem. 2021 Aug 26;64(16):11886-11903.

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