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Chemical Structure : CC260
Catalog No.: PC-72563Not For Human Use, Lab Use Only.
CC260 (CC-260) is a potent, selective inhitor of PI5P4Kα/β with Ki of 40/30 nM, respectively.
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CC260 (CC-260) is a potent, selective inhitor of PI5P4Kα/β with Ki of 40/30 nM, respectively.
CC260 displays high selectivity against a panel of 396 protein kinases, modestly inhibits PIKfyve (Ki=200 nM), does not inhibit most PI3Ks, PI4Ks, or SphKs but modestly inhibits PI3K-γ (Ki ∼200 nM) and PI3K-δ (Ki ∼120 nM).
CC260 enhanced insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppressed S6K phosphorylation by mTORC1, disrupted energy homeostasis in myotubes, selectively toxic toward p53-null tumor cells.
CC260 reduced tumor cell survival under nutrient stress.
| M.Wt | 490.429 | |
| Formula | C24H29Cl2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Song Chen, et al. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2002486118.
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