Chemical Structure : CCF0054500
CAS No.:
887902-01-4
CCF0054500
(CCF-0054500)
Catalog No.: PC-26506Not For Human Use, Lab Use Only.
CCF0054500 is a specific small molecule agonist of orphan GPCR OR2L13, inhibits inhibit platelet aggregation in platelet-rich plasma (PRP) with EC50 of 14 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CCF0054500 is a specific small molecule agonist of orphan GPCR OR2L13, inhibits inhibit platelet aggregation in platelet-rich plasma (PRP) with EC50 of 14 uM.
CCF0054500 broadly inhibits platelet reactivity through PAR1, P2Y12, GPVI (glycoprotein VI), and thromboxane receptors, as well as GPIIb/IIIa, uniquely inhibiting both biochemical and biomechanical activation of the platelet.phosphorylated platelet HSP27 (heat shock protein 27), disrupting the actin cytoskeleton and reducing clot retraction.
CCF0054500 reorganizes the platelet actin cytoskeleton by promoting F-actin depolymerization without diminishing the cytoskeleton globular actin pool, thereby modulating thrombosis-related platelet shape change while preserving physiologic hemostatic function.
Physicochemical Properties
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M.Wt
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400.54
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Formula
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C22H28N2O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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ethyl 5,5,7,7-tetramethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
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References
1. Anu Aggarwal, et al. Circulation. 2026 Apr 7. doi: 10.1161/CIRCULATIONAHA.
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