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Chemical Structure : CCF642
CAS No.: 346640-08-2
Catalog No.: PC-42153Not For Human Use, Lab Use Only.
CCF642 (CCF 642) is a novel covalent protein disulfide isomerase (PDI) inhibitor with IC50 of 2.9 uM, shows antimyeloma activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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CCF642 (CCF 642) is a novel covalent protein disulfide isomerase (PDI) inhibitor with IC50 of 2.9 uM, shows antimyeloma activity.
CCF642 inhibits PDI reductase activity about 100-fold more potently than PACMA 31 and LOC14.
CCF642 shows cytotoxicity against MM cells with a submicromolar IC50, causes acute ER stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release.
CCF642 displays potent efficacy and prolongs the lifespan in an aggressive syngeneic mouse model of multiple myeloma.
| M.Wt | 378.4459 | |
| Formula | C15H10N2O4S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
4-Thiazolidinone, 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo- |
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1. Vatolin S, et al. Cancer Res. 2016 Jun 1;76(11):3340-50.
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