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Chemical Structure : CCG-1423
CAS No.: 285986-88-1
Catalog No.: PC-22494Not For Human Use, Lab Use Only.
CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $68 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $288 | In stock | |
| 250 mg | Get quote |
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CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer.
CCG-1423 blocks transcription activated by MKL1, but not that induced by SRF-VP16 or GAL4-VP16.
CCG-1423 inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, and inhibits the growth of RhoC-overexpressing melanoma lines (A375M2 and SK-Mel-147) at nanomolar concentrations.
CCG-1423 is less active on related lines (A375 and SK-Mel-28) that express lower levels of Rho.
CCG-1423 selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell line (A375M2) compared with the parental cell line (A375).
CCG-1423 inhibits Rho-dependent invasion by PC-3 prostate cancer cells, wherea it does not affect the Gαi-dependent invasion by the SKOV-3 ovarian cancer cell line.
| M.Wt | 454.75 | |
| Formula | C18H13ClF6N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((1-((4-Chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide |
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1. Evelyn CR, et al. Mol Cancer Ther. 2007 Aug;6(8):2249-60.
2. Jin W, et al. J Clin Invest. 2011 Mar;121(3):918-29.
3. Evelyn CR, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):665-72.
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