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Chemical Structure : CCG-222740
CAS No.: 1922098-69-8
Catalog No.: PC-35330Not For Human Use, Lab Use Only.
CCG-222740 (CCG222740) is a pharmacological inhibitor of MRTF/SRF signalling, shows greater inhibitory effect on MRTF/SRF target genes than MRTF-A inhibitor CCG-203971, with IC50 of 5 uM in fibroblast-mediated collagen contraction assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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CCG-222740 (CCG222740) is a pharmacological inhibitor of MRTF/SRF signalling, shows greater inhibitory effect on MRTF/SRF target genes than MRTF-A inhibitor CCG-203971, with IC50 of 5 uM in fibroblast-mediated collagen contraction assay.
CCG-222740 is a more potent inhibitor of alpha-smooth muscle actin protein expression than CCG-203971.
CCG-222740 prevents scar tissue formation in a preclinical model of fibrosis; effectively kills BRAFi-resistant melanoma cells.
| M.Wt | 444.863 | |
| Formula | C23H19ClF2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide |
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1. Hutchings KM, et al. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1744-1749.
2. Yu-Wai-Man C, et al. Sci Rep. 2017 Mar 31;7(1):518.
3. Sean A. Misek, et al. Abstract 5895: Targeting RhoA-regulated gene transcription in drug-resistant melanoma. AACR 2018.
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