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Chemical Structure : CCG-63808
CAS No.: 620113-73-7
Catalog No.: PC-45956Not For Human Use, Lab Use Only.
A reversible, allosteric inhibitor of regulator of G-protein signaling (RGS) proteins with a potency order of RGS4 >19=16>8>>7.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CCG-63808 is a reversible, allosteric inhibitor of regulator of G-protein signaling (RGS) proteins with a potency order of RGS4 >19=16>8>>7.
CCG-63808 inhibits the Gαo-RGS4 interaction with IC50 of 1.9 uM, does not inhibit Gα binding to RGS7, 2- to 10-fold more potent at RGS4 than on the other closely related R4 family members, RGS8 and RGS16.
| M.Wt | 454.4756 | |
| Formula | C25H15FN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Benzothiazoleacetonitrile, .alpha.-[[2-(4-fluorophenoxy)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]- |
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1. Blazer LL, et al. Mol Pharmacol. 2010 Sep;78(3):524-33.
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