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CCR4-351

Chemical Structure : CCR4-351

CAS No.: 2174938-70-4

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CCR4-351 (CCR4-IN-38)

Catalog No.: PC-73031Not For Human Use, Lab Use Only.

CCR4-IN-38 (CCR4-351) is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 50 nM (Chemotaxis inhibition).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CCR4-IN-38 (CCR4-351) is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 50 nM (Chemotaxis inhibition).
    CCR4-IN-38 inhibits the recruitment of Treg into the tumor microenvironment (TME).
    CCR4-IN-38 elicits antitumor responses as a single agent or in combination with an immune checkpoint blockade.

    Physicochemical Properties

    M.Wt 500.428
    Formula C24H27Cl2N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-((R)-1-(2,4-dichlorophenyl)ethyl)-6-(3-((R)-1-(2-hydroxyethyl)piperidin-3-yl)azetidin-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile

    References

    1. Omar Robles, et al. J Med Chem. 2020 Aug 13;63(15):8584-8607.

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