CCR4-IN-31

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Chemical Structure : CCR4-IN-31

Catalog No.: PC-73030Not For Human Use, Lab Use Only.

CCR4-IN-31 is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 40 nM (Ca2+ flux).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CCR4-IN-31 is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 40 nM (Ca2+ flux).
CCR4-IN-31 exhibited high potency in distinct functional assays in addition to good in vitro and in vivo ADME properties.
CCR4-IN-31 potentiate antitumor immune responses.

Physicochemical Properties

M.Wt	511.451
Formula	C26H28Cl2N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((R)-1-(2,4-dichlorophenyl)ethyl)-6-((4S,5R)-4-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-5-methylcyclohex-1-en-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile

References

1. Jackson JJ, et al. J Med Chem. 2019 Jul 11;62(13):6190-6213.

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CCR4-IN-31

Biological Activity

Physicochemical Properties

References

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