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CCT-031374

Chemical Structure : CCT-031374

CAS No.: 442535-46-8

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CCT-031374 (CCT031374)

Catalog No.: PC-62168Not For Human Use, Lab Use Only.

CCT-031374 (CCT031374) is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CCT-031374 (CCT031374) is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM.
    CCT-031374 prevents BIO-induced accumulation of β-catenin, does not alter β-catenin levels but blocks transcription at the β-catenin level。
    CCT-031374 also shows activity against endogenous LEF-1 mRNA levels in human neurogenic embryoid bodies (hNEBs) in which Wnt signaling had been induced by BIO.

    Physicochemical Properties

    M.Wt 353.425
    Formula C23H19N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone

    References

    1. Ewan K, et al. Cancer Res. 2010 Jul 15;70(14):5963-73.

    2. Yang Y, et al. Neuroscience. 2013 Sep 17;248:383-91.

    3. Liu B, et al. Int J Mol Med. 2015 Dec;36(6):1572-82.

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