CCT018159 | DDX39B inhibitor, Hsp90 inhibitor

Chemical Structure : CCT018159

CAS No.: 171009-07-7

CCT018159 (CCT-018159, CCT 018159)

Catalog No.: PC-61633Not For Human Use, Lab Use Only.

CCT018159 is al potent inhibitor of Hsp90 ATPase activity with IC50 of 7.1 uM, also inhibits the ATPase activity of R-loop unwinding helicase DDX39B (UAP56).

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

CCT018159 is al potent inhibitor of Hsp90 ATPase activity with IC50 of 7.1 uM, also inhibits the ATPase activity of R-loop unwinding helicase DDX39B (UAP56).

CCT018159 inhibits recombinant UAP56 ATPase activity with Ki of 5.5 uM, reduces UAP56 activity by >70% at 100 µM (IC50=64.3 uM).

CCT018159 disrupts vRNP formation without inhibiting cellular mRNA export.

CCT018159 prevents KSHV lytic replication.

CCT018159 shows a mean cellular GI50 of 5.3 uM across a panel of human cancer cell lines.

CCT018159 causes cell cytostasis associated with a G(1) arrest and induces apoptosis, also inhibites key endothelial and tumor cell functions implicated in invasion and angiogenesis.

Physicochemical Properties

M.Wt	352.39
Formula	C20H20N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol

References

1. Jing R, et al. Development. 2017 May 15;144(10):1764-1774.

2. Sharp SY, et al. Cancer Res. 2007 Mar 1;67(5):2206-16.

3. Schumann S, et al. Nat Microbiol. 2016 Oct 31;2:16201.

4. Beloueche-Babari M, et al. Oncotarget. 2010 Jul;1(3):185-97.

CCT018159 (CCT-018159, CCT 018159)

Biological Activity

Physicochemical Properties

References

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