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Chemical Structure : CCT068127
Catalog No.: PC-62561Not For Human Use, Lab Use Only.
CCT068127 (CCT68127) is a novel potent inhibitor of CDK2 and CDK9 with IC50 of 10 and 90 nM for CDK2/E and CDK9/T, respectively.
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CCT068127 (CCT68127) is a novel potent inhibitor of CDK2 and CDK9 with IC50 of 10 and 90 nM for CDK2/E and CDK9/T, respectively.
CCT068127 also inhibits CDK5/p35, CDK2/A, CDK7/H with IC50 of <1 uM, but without significant activity against ABL, AKT, CAMKII, CK2, ERK2, GSK3 etc.
CCT068127 treatment causes a dramatic loss in expression of DUSP6 phosphatase, alongside elevated ERK phosphorylation and activation of MAPK pathway target genes in cancer cells.
| M.Wt | 369.473 | |
| Formula | C19H27N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Whittaker SR, et al. Mol Oncol. 2017 Oct 24. doi: 10.1002/1878-0261.12148.
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