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Chemical Structure : CCT 137690
CAS No.: 1095382-05-0
Catalog No.: PC-42703Not For Human Use, Lab Use Only.
CCT 137690 is a potent, orally bioavailable Aurora kinases inhibitor with IC50 of 15/25/19 nM for Aurora A/B/C, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $528 | In stock | |
| 250 mg | Get quote |
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CCT 137690 is a potent, orally bioavailable Aurora kinases inhibitor with IC50 of 15/25/19 nM for Aurora A/B/C, respectively.
CCT 137690 displays antiproliferative activity in a range of human tumor cell lines, including SW620 colon carcinoma (GI50=0.30 uM) and A2780 ovarian cancer cell line (GI50=0.14 uM).
CCT 137690 exhibits in vivo efficacy with no observed toxicities in SW620 colon carcinoma xenografts.
| M.Wt | 551.4813 | |
| Formula | C26H31BrN8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3H-Imidazo[4,5-b]pyridine, 6-bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]- |
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1. Bavetsias V, et al. J Med Chem. 2010 Jul 22;53(14):5213-28.
2. Faisal A, et al. Mol Cancer Ther. 2011 Nov;10(11):2115-23.
3. Moore AS, et al. Leukemia. 2012 Jul;26(7):1462-70.
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