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Chemical Structure : CCT241533 hydrochloride
CAS No.: 1431697-96-9
Catalog No.: PC-44033Not For Human Use, Lab Use Only.
CCT241533 hydrochloride is a potent and selective ATP-competitive inhibitor of CHK2 with IC50 of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
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CCT241533 hydrochloride is a potent and selective ATP-competitive inhibitor of CHK2 with IC50 of 3 nM.
CCT241533 shows good selectivity for CHK2 against CHK1 (IC50=180 nM) and a wider panel of kinases and with promising in vitro ADMET properties.
CCT241533 inhibits CHK2 autophosphorylation at S516, band shift mobility changes, and HDMX degradation.
| M.Wt | 478.9442 | |
| Formula | C23H28ClFN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-fluoro-2-(4-(((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)amino)-6,7-dimethoxyquinazolin-2-yl)phenol hydrochloride |
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1. Caldwell JJ, et al. J Med Chem. 2011 Jan 27;54(2):580-90.
2. Anderson VE, et al. Cancer Res. 2011 Jan 15;71(2):463-72.
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