CCT251236 (CCT-251236) is a potent, orally available Pirin ligand (Ki=28 nM), blocks the HSF1-mediated induction of both HSP72 and HSP27.
CCT251236 inhibits the induction of HSP72 at the mRNA level, blocks the induction of HSPA1A gene expression with IC50 of 40 nM, inhibits SK-OV-3 cells proliferation with GI50 of 1.1 nM.
CCT251236 displays efficacy in a human ovarian carcinoma xenograft model.
