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CCT271850

Chemical Structure : CCT271850

CAS No.: 1578244-34-4

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CCT271850 (CCT-271850)

Catalog No.: PC-60230Not For Human Use, Lab Use Only.

CCT271850 is a potent, selective, orally bioavailable Mps1 kinase (TTK) inhibitor with IC50 of 11 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CCT271850 is a potent, selective, orally bioavailable Mps1 kinase (TTK) inhibitor with IC50 of 11 nM.
    CCT271850 displays >1,000-fold selectivity over CDK-2, Aurora A/B and PLK1.
    CCT271850 inhibits HCT116 cells growth with GI50 of 0.16 uM, sensitises selectively MSI+ colon cancer and basal breast cancer cell lines to cell death; active in vivo.

    Physicochemical Properties

    M.Wt 431.544
    Formula C24H29N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N8-(3,3-dimethylbutan-2-yl)-N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine

    References

    1. Faisal A, et al. Br J Cancer. 2017 Apr 25;116(9):1166-1176.

    2. Innocenti P, et al. J Med Chem. 2016 Apr 28;59(8):3671-88.

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