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Chemical Structure : CCT365623
CAS No.: 2126134-01-6
Catalog No.: PC-61189Not For Human Use, Lab Use Only.
CCT365623 (CCT-365623) is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CCT365623 (CCT-365623) is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM.
CCT365623 is ∼16-fold more potent than BAPN (IC50=14.7 uM).
CCT365623 displays excellent selectivity (over 350-fold) for LOX over amine oxidase A and B (MAO-A, MAO-B) and is over 1,000-fold more selective for LOX over serum diamine oxidase.
CCT365623 inhibits LOX at ∼5 μM in MDCK cysts, whereas BAPN inhibits LOX at ∼250 μM.
CCT365623 suppresses EGFR and AKT phosphorylation driven by EGF, also inhibits HTRA1 multimer formation.
CCT365623 blocks tumour growth and metastasis in a mouse model of spontaneous breast cancer that metastasizes to the lungs.
| M.Wt | 407.517 | |
| Formula | C18H17NO4S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5-((5-(methylsulfonyl)-[1,1'-biphenyl]-3-yl)sulfonyl)thiophen-2-yl)methanamine |
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1. Tang H, et al. Nat Commun. 2017 Apr 18;8:14909.
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