CCT365623 (CCT-365623) hydrochloride is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM.
CCT365623 inhibits LOX actvity in living cell system (MDCK cysts) at 5 uM, reduces EGFR retention at the cell surface, suppresses EGFR and AKT phosphorylation driven by EGF.
CCT365623 also activates SMAD2 and downregulates MATN2.
CCT365623 delays the growth of primary and metastatic tumour cells in vivo.
