CCX-771 |CAS:N/A Probechem Biochemicals

Chemical Structure : CCX-771

CCX-771 (CCX 771;CCX771)

Catalog No.: PC-60212Not For Human Use, Lab Use Only.

CCX-771 is a potent, selective CXCR7 antagonist with IC50 of 4.1 nM.

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Biological Activity

CCX-771 is a potent, selective CXCR7 antagonist with IC50 of 4.1 nM.
CCX-771 potently inhibits CXCL12-induced NC-37 cell transendothelial migration (TEM) with IC50 of 49 nM, 20 times greater than that of AMD3100 (IC50=830 nM).
CCX-771 also potently stimulates β-arrestin2 recruitment to CXCR7, with greater potency and efficacy than the endogenous chemokine ligands.
CCX-771 inhibits lesion formation and ameliorates hyperlipidemia after vascular injury and during atherosclerosis in Apoe(-/-) mice.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

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CCX-771 (CCX 771;CCX771)

Biological Activity

Physicochemical Properties

References

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