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CCX-771

Chemical Structure : CCX-771

CAS No.:

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CCX-771 (CCX 771;CCX771)

Catalog No.: PC-60212Not For Human Use, Lab Use Only.

CCX-771 is a potent, selective CXCR7 antagonist with IC50 of 4.1 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CCX-771 is a potent, selective CXCR7 antagonist with IC50 of 4.1 nM.
CCX-771 potently inhibits CXCL12-induced NC-37 cell transendothelial migration (TEM) with IC50 of 49 nM, 20 times greater than that of AMD3100 (IC50=830 nM).
CCX-771 also potently stimulates β-arrestin2 recruitment to CXCR7, with greater potency and efficacy than the endogenous chemokine ligands.
CCX-771 inhibits lesion formation and ameliorates hyperlipidemia after vascular injury and during atherosclerosis in Apoe(-/-) mice.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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