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Chemical Structure : CD 437
CAS No.: 125316-60-1
Catalog No.: PC-62291Not For Human Use, Lab Use Only.
CD437 (CD 437) is a retinoid-like small molecule that selectively induces apoptosis in cancer cells, but not in normal cells, directly inhibits DNA polymerase α with IC50 of 22 nM, also acts as an RARγ agonist.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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CD437 (CD 437) is a retinoid-like small molecule that selectively induces apoptosis in cancer cells, but not in normal cells, directly inhibits DNA polymerase α with IC50 of 22 nM, also acts as an RARγ agonist.
CD437 shows weak activity against POLA1 L700S or the L764S mutation (IC50:1.2 uM, 2.6 uM, rspectively).
CD437 inhibits the growth of both ATRA-sensitive (CA-OV-3) and ATRA-resistant (SK-OV-3) ovarian tumor cells, and induces apoptosis.
| M.Wt | 398.5 | |
| Formula | C27H26O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid |
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1. Han T, et al. Nat Chem Biol. 2016 Jul;12(7):511-5.
2. Holmes WF, et al. J Cell Biochem. 2003 May 15;89(2):262-78.
3. Mologni L, et al. Blood. 1999 Feb 1;93(3):1045-61.
4. Benedetti L, et al. Blood. 1996 Mar 1;87(5):1939-50.
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