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Chemical Structure : CDD-2693
Catalog No.: PC-22284Not For Human Use, Lab Use Only.
CDD-2693 (CDD2693) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 4.0/0.81 nM, respectively.
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CDD-2693 (CDD2693) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 4.0/0.81 nM, respectively.
CDD-2693 shows nanomolar activity versus EPHA2 (IC50: 461 nM) and EPHA4 (IC50: 40 nM) but is a micromolar inhibitor of SRC, YES, and FGR.
CDD-2693 significantly decreases EFNA5 (ligand) induced phosphorylation of EPHA2/4, decreases 12Z cell viability, and decreases IL-1β-mediated expression of prostaglandin synthase 2 (PTGS2) in 12Z endometriotic epithelial cells.
CDD-2693 decreases expansion of primary endometrial epithelial organoids from patients with endometriosis and decreases Ewing's sarcoma viability.
| M.Wt | 489.59 | |
| Formula | C29H32FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Madasu C, et al. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322934121.
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